Article
Alloreactive 2C T cells recognize a self peptide in the context of the mutant Kbm3 molecule.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1995
Tallquist M D, Pease L R
Abstract excerpt
Previous studies hav shown that 2C T cells have dual specificity for Ld and Kbm3 alloantigens and are positively selected in the context of Kb. Analysis of Kbm3-eluted peptides reveals a single HPLC fraction that is a central component of the Kbm3 allodeterminant. Peptides with biologic and biochemical properties indistinguishable from those of the Kbm3 allopeptide were also isolated from Kb and Kbm8, despite the...
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