Article
Ligation of MHC class I molecules on peripheral blood T lymphocytes induces new phenotypes and functions.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1996
Bregenholt S, Röpke M, Skov S, Claesson M H
Abstract excerpt
Microgram concentrations of immobilized anti-MHC class I (MHC-I) Ab induced proliferation of resting CD3+ T cells from peripheral blood. In contrast, soluble Ab did not activate T cells. Exposure of T cells to immobilized anti-MHC-I Ab for only 24 h was followed by proliferation and development o...
Topics
- Antibodies, Monoclonal
- CD28 Antigens
- CD3 Complex
- Cell Division
- Cytotoxicity, Immunologic
- Dose-Response Relationship, Immunologic
- Histocompatibility Antigens Class I
- Humans
- In Vitro Techniques
- Phenotype
- Phosphorylation
- Protein-Tyrosine Kinases
- Receptors, Antigen, T-Cell
- T-Lymphocyte Subsets
- Time Factors