Article
The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.
Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 1996
Racioppi L, Matarese G, D'Oro U, De Pascale M, Masci A M, Fontana S, Zappacosta S
Abstract excerpt
Small changes in the complex between a peptide and a molecule of the major histocompatibility complex generate ligands able to partially activate (partial agonist) or even inhibit (antagonist) T-cell functions. T-cell receptor engagement of antagonist complex results in a partial zeta chain phosphorylation without activation of the associated ZAP-70 kinase. Herein we show that, despite a strong inhibition of both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.