Article
CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion.
The Journal of experimental medicine - 7 Apr 1997
Wu Y, Guo Y, Huang A, Zheng P, Liu Y
Abstract excerpt
T cell costimulation, particularly by the B7 family members B7-1 and B7-2, plays a critical role in regulating T cell-mediated immunity. Two molecules on T cells, CD28 and CTLA-4, are known to bind to B7. It has been suggested that CD28-B7 interaction promotes T cell response, whereas B7-CTLA-4 interaction downregulates T cell clonal expansion. However, the proposed responses of individual receptors to B7 have...
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