Article
CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion.
The Journal of experimental medicine - 7 Apr 1997
Wu Y, Guo Y, Huang A, Zheng P, Liu Y
Abstract excerpt
T cell costimulation, particularly by the B7 family members B7-1 and B7-2, plays a critical role in regulating T cell-mediated immunity. Two molecules on T cells, CD28 and CTLA-4, are known to bind to B7. It has been suggested that CD28-B7 interaction promotes T cell response, whereas B7-CTLA-4 i...
Topics
- Abatacept
- Animals
- Antigens, CD
- Antigens, Differentiation
- B7-1 Antigen
- CD28 Antigens
- CHO Cells
- CTLA-4 Antigen
- Cricetinae
- Immunoconjugates
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Protein Binding
- Recombinant Fusion Proteins
- T-Lymphocytes