Article
Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2001
Morgan M M, Labno C M, Van Seventer G A, Denny M F, Straus D B, Burkhardt J K
Abstract excerpt
The formation of a conjugate between a T cell and an APC requires the activation of integrins on the T cell surface and remodeling of cytoskeletal elements at the cell-cell contact site via inside-out signaling. The early events in this signaling pathway are not well understood, and may differ from the events involved in adhesion to immobilized ligands. We find that conjugate formation between Jurkat T cells and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.