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Article

Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1995

al-Ramadi B K, Jelonek M T, Boyd L F, Margulies D H, Bothwell A L

Abstract excerpt

We describe a comprehensive analysis of the effect of avidity of TCR-MHC/peptide interaction on activation of the (p2Ca). In study, monosubstituted variants of p2Ca were used and assessed for binding to purified H-2Ld, binding of H-2Ld/peptide complexes to sTCR, and ability to activate 2C cells to two independent effector functions. Among the > 20 variants analyzed, functional activity of most peptides that bound...

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PMID: 7541822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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