Article
Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1995
al-Ramadi B K, Jelonek M T, Boyd L F, Margulies D H, Bothwell A L
Abstract excerpt
We describe a comprehensive analysis of the effect of avidity of TCR-MHC/peptide interaction on activation of the (p2Ca). In study, monosubstituted variants of p2Ca were used and assessed for binding to purified H-2Ld, binding of H-2Ld/peptide complexes to sTCR, and ability to activate 2C cells to two independent effector functions. Among the > 20 variants analyzed, functional activity of most peptides that bound...
Topics
- Amino Acid Sequence
- Animals
- CD8 Antigens
- Cell Line
- Cytotoxicity, Immunologic
- Epitopes
- Genetic Variation
- H-2 Antigens
- Histocompatibility Antigens Class I
- Interleukin-3
- Mice