Murine neurovirulence studies with a chimeric poliovirus: in vivo generation of a mutant base-paired stable attenuated poliovirus.

doi:10.1006/mpat.1998.0231

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Article

Murine neurovirulence studies with a chimeric poliovirus: in vivo generation of a mutant base-paired stable attenuated poliovirus.

Microbial pathogenesis - 1 Oct 1998

Lee C, Young C

Abstract excerpt

We investigated the neurovirulence of a chimeric poliovirus consisting of the coding region of Lansing type 2 poliovirus and the 5'NCR of type 3 poliovirus. Specifically we carried out studies on the effects of stable base pairing, between nucleotides 472 and 537, on neurovirulence. Mice were inj...

Topics

Animals
Base Sequence
Brain
Cell Line
Cytopathogenic Effect, Viral
Humans
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mutation
Poliovirus
Poliovirus Vaccine, Inactivated
RNA, Viral
Vaccines, Attenuated
Viral Plaque Assay
Virulence

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