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Article

Host range determinants located on the interior of the poliovirus capsid.

The EMBO journal - 1 May 1991

Moss E G, Racaniello V R

Abstract excerpt

The inability of certain poliovirus strains to infect mice can be overcome by the expression of human poliovirus receptors in mice or by the presence of a particular amino acid sequence of the B-C loop of the viral capsid protein VP1. We have identified changes in an additional capsid structure that permit host-restricted poliovirus strains to infect mice. Variants of the mouse-virulent P2/Lansing strain were...

Topics

Alleles
Animals
Capsid
Capsid Proteins
HeLa Cells
Humans
Hydrolysis
Mice
Mice, Transgenic
Phenotype
Poliovirus
Protein Conformation
Receptors, Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Suppression, Genetic

Transfection

Trypsin

Viral Plaque Assay

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 1850692
DOI: 10.1002/j.1460-2075.1991.tb08046.x
PMCID: PMC452759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1850692-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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