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Article

Identification of two determinants that attenuate vaccine-related type 2 poliovirus

1 Mar 1991

Abstract excerpt

The poliovirus P2/P712 strain is an attenuated virus that is closely related to the type 2 Sabin vaccine strain. By using a mouse model for poliomyelitis, sequences responsible for attenuation of the P2/P712 strain were previously mapped to the 5' noncoding region of the genome and a central region encoding VP1, 2Apro, 2B, and part of 2C. To identify specific determinants that attenuate the P2/P712 strain,...

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Identifiers

PMID: 1847458
DOI: 10.1128/jvi.65.3.1377-1382.1991

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