Mutations in the UL53 gene of HSV-1 abolish virus neurovirulence to mice by the intracerebral route of infection.

Abstract excerpt

The cell fusion protein, the product of the UL53 gene, is responsible for intracerebral (IC) pathogenicity of HSV-1. Recombinant HSV-1 R15 is apathogenic to mice by the IC route of inoculation, while intratypic recombinants, in which the UL53 gene in R15 was replaced by an analogous sequence from the pathogenic strain R19, regained IC pathogenicity. The nucleotide sequence of the UL53 gene of HSV-1 strains R15...

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Brain
• DNA, Viral
• Female
• Gene Expression
• Genes, Viral
• Herpes Simplex
• Mice
• Mice, Inbred A
• Molecular Sequence Data