Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice.

Abstract excerpt

This study has identified a single amino acid change in the viral glycoprotein that profoundly affects the ability of lymphocytic choriomeningitis virus (LCMV) to persist in its natural host. Adult immunocompetent mice infected with a variant of the Armstrong strain, spleen isolate clone 13 (svA/svA), harbor virus for several months and exhibit suppressed T cell responses. In contrast, adult mice infected with a...

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Glycoproteins
• Lymphocytic choriomeningitis virus
• Mice
• Mice, Inbred BALB C
• Molecular Sequence Data
• Mutation
• T-Lymphocytes, Cytotoxic