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Article

A role for dual viral hits in causation of subacute sclerosing panencephalitis.

The Journal of experimental medicine - 7 Nov 2005

Oldstone Michael B A, Dales Samuel, Tishon Antoinette, Lewicki Hanna, Martin Lee

Abstract excerpt

Subacute sclerosing panencephalitis (SSPE) is a progressive fatal neurodegenerative disease associated with persistent infection of the central nervous system (CNS) by measles virus (MV), biased hypermutations of the viral genome affecting primarily the matrix (M) gene with the conversion of U to C and A to G bases, high titers of antibodies to MV, and infiltration of B cells and T cells into the CNS. Neither the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16260490
DOI: 10.1084/jem.20051376
PMCID: PMC1350947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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