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Article

Identification and characterization of a new base substitution in the vaccine strain of Sabin 3 poliovirus.

Virology - 1 Dec 1991

Weeks-Levy C, Tatem J M, DiMichele S J, Waterfield W, Georgiu A F, Mento S J

Abstract excerpt

The complete RNA sequence of Sabin 3 (LED3) used in vaccine in the United States has been determined. The LED3 Sabin 3 sequence contains the attenuating mutations at bases 472 and 2034 but differs from that published by Stanway et al. (Nucleic Acids Res., 11, 5629-5643, 1983) at two other base positions, 2493 and 6061. The change at base 6061 is silent and does not affect amino acid composition. The other base, a...

Topics

Animals
Capsid
Capsid Proteins
Genetic Variation
Haplorhini
Mutation
Poliovirus
Poliovirus Vaccine, Oral
Selection, Genetic
Virulence

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Identifiers

PMID: 1660210
DOI: 10.1016/0042-6822(91)90576-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1660210-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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