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Article

Identification and characterization of a new base substitution in the vaccine strain of Sabin 3 poliovirus.

Virology - 1 Dec 1991

Weeks-Levy C, Tatem J M, DiMichele S J, Waterfield W, Georgiu A F, Mento S J

Abstract excerpt

The complete RNA sequence of Sabin 3 (LED3) used in vaccine in the United States has been determined. The LED3 Sabin 3 sequence contains the attenuating mutations at bases 472 and 2034 but differs from that published by Stanway et al. (Nucleic Acids Res., 11, 5629-5643, 1983) at two other base positions, 2493 and 6061. The change at base 6061 is silent and does not affect amino acid composition. The other base, a...

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PMID: 1660210
DOI: 10.1016/0042-6822(91)90576-w

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