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Article

A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice

1 Aug 1993

Abstract excerpt

The attenuated Sabin strain of poliovirus type 1 (PV-1) differs from the neurovirulent PV-1 Mahoney strain by 55 nucleotide mutations. Only one of these mutations (A-480-->G, in the 5' noncoding (5' NC) region of the genome, is well characterized, and it confers a strong attenuating effect. We attempted to identify genetic attenuation determinants in the 3'-terminal part of the Sabin 1 genome including the 3D...

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PMID: 8392604
DOI: 10.1128/jvi.67.8.4630-4638.1993

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A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in micePMID 8392604Read ↗

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