Article
Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus.
Journal of virology - 1 Dec 1993
Matloubian M, Kolhekar S R, Somasundaram T, Ahmed R
Abstract excerpt
This study documents that the immunosuppressive lymphocytic choriomeningitis virus (LCMV) variant, clone 13, shows a specific predilection for enhanced infection of macrophages both in vitro and in vivo and that single amino acid changes in the viral polymerase and glycoprotein are responsible fo...
Topics
- Animals
- Genetic Variation
- Glycoproteins
- Kupffer Cells
- Lymphocytic Choriomeningitis
- Lymphocytic choriomeningitis virus
- Macrophages
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- RNA-Directed DNA Polymerase
- Sequence Analysis
- Spleen
- Viral Proteins