Article
No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia.
Neuroscience letters - 1 May 1998
Taddei K, Yang D, Fisher C, Clarnette R, Hallmayer J, Barnetson R, Maller R, Brooks W S, Whyte S, Nicholson G A, Masters C L, Broe G A, Gandy S E, Martins R N
Abstract excerpt
We screened 703 Australian subjects for an intronic polymorphism in the presenilin-1 (PS-1) gene. PS-1 intronic allele 1 homozygosity was not associated with individuals with early- or late-onset sporadic Alzheimer's disease (EOAD or LOAD). Carriers for the PS-1 intronic allele 1 were also not as...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Australia
- DNA
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genetic Linkage
- Genetic Testing
- Genotype