No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples.

Article

No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples.

American journal of medical genetics - 18 Apr 1997

Cai X, Stanton J, Fallin D, Hoyne J, Duara R, Gold M, Sevush S, Scibelli P, Crawford F, Mullan M

Abstract excerpt

Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an exc...

Topics

Alleles
Alzheimer Disease
Homozygote
Humans
Introns
Membrane Proteins
Polymorphism, Genetic
Presenilin-1

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