Article
No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples.
American journal of medical genetics - 18 Apr 1997
Cai X, Stanton J, Fallin D, Hoyne J, Duara R, Gold M, Sevush S, Scibelli P, Crawford F, Mullan M
Abstract excerpt
Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess of homozygotes for the more common allele (allele 1) in AD cases, associated with an approximate doubling of risk....
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