No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease.

doi:10.1016/s0304-3940(97)00653-8

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Article

No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease.

Neuroscience letters - 26 Sept 1997

Singleton A B, Lamb H, Leake A, McKeith I G, Perry R H, Morris C M

Abstract excerpt

Mutations in the presenilin-1 (PS-1) gene are believed to be responsible for the majority of familial early-onset Alzheimer's disease (AD). The finding of an intronic polymorphism in the PS-1 gene prompted an investigation into its relevance in AD. An association between homozygosity for the most...

Topics

Alleles
Alzheimer Disease
Case-Control Studies
Chi-Square Distribution
Genotype
Homozygote
Humans
Introns
Membrane Proteins
Polymorphism, Genetic
Presenilin-1

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