Article
No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease.
Neuroscience letters - 26 Sept 1997
Singleton A B, Lamb H, Leake A, McKeith I G, Perry R H, Morris C M
Abstract excerpt
Mutations in the presenilin-1 (PS-1) gene are believed to be responsible for the majority of familial early-onset Alzheimer's disease (AD). The finding of an intronic polymorphism in the PS-1 gene prompted an investigation into its relevance in AD. An association between homozygosity for the most common allele (allele 1) in this intronic polymorphism and late-onset AD has been shown and has been confirmed by...
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