Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease.

doi:10.1016/s0006-8993(98)01005-1

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Article

Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease.

Brain research - 23 Jan 1999

Liao A, Gómez-Isla T, Clatworthy A, Hyman B T

Abstract excerpt

Over 45 mutations within the coding region of presenilin-1 (PS-1) are associated with an autosomal dominant form of Alzheimer's disease. Recently allele 1 of a polymorphism within intron-8 was reported to be in disequilibrium with Alzheimer's disease in a group of patients with sporadic Alzheimer...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Female
Genes, Dominant
Genotype
Humans
Introns
Male
Membrane Proteins
Polymorphism, Genetic
Presenilin-1

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