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Article

Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease.

Brain research - 23 Jan 1999

Liao A, Gómez-Isla T, Clatworthy A, Hyman B T

Abstract excerpt

Over 45 mutations within the coding region of presenilin-1 (PS-1) are associated with an autosomal dominant form of Alzheimer's disease. Recently allele 1 of a polymorphism within intron-8 was reported to be in disequilibrium with Alzheimer's disease in a group of patients with sporadic Alzheimer's disease. This association has been replicated in some, but not all, studies. To determine whether the PS-1 intronic...

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Source

Identifiers

PMID: 9878795
DOI: 10.1016/s0006-8993(98)01005-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease.PMID 9878795Read ↗

Presenilin 1 intronic polymorphism is not associated with Alzheimer type neuropathological changes or sporadic Alzheimer's disease.Semantic proximity Read ↗

No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease.Semantic proximity Read ↗

Presenilin-1 intron 8 polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease.Semantic proximity Read ↗

Association between a PS-1 intronic polymorphism and late onset Alzheimer's disease.Semantic proximity Read ↗

No association between a presenilin 1 polymorphism and Alzheimer disease.Semantic proximity Read ↗

An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposited in Alzheimer's disease.Semantic proximity Read ↗

No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population.Semantic proximity Read ↗

No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease.Semantic proximity Read ↗

No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples.Semantic proximity Read ↗

No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia.Semantic proximity Read ↗

No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies.Semantic proximity Read ↗

Presenilin-1 gene intronic polymorphism in sporadic and familial Alzheimer's disease.Semantic proximity Read ↗

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