No association between a presenilin 1 polymorphism and Alzheimer disease.

doi:10.1001/archneur.57.5.699

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Article

No association between a presenilin 1 polymorphism and Alzheimer disease.

Archives of neurology - 1 May 2000

Romas S N, Mayeux R, Tang M X, Lantigua R, Medrano M, Tycko B, Knowles J

Abstract excerpt

BACKGROUND: Homozygosity of allele 1 of a presenilin 1 intron 8 polymorphism (PS1-1) has been associated with doubling of the risk of sporadic late-onset Alzheimer disease (LOAD), in some, but not all studies. OBJECTIVE: To genotype the PS1 intron 8 polymorphism in predominantly Hispanic families with LOAD to test for association and for linkage between this polymorphism and LOAD. DESIGN: A family-based,...

Topics

Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Case-Control Studies
Female
Genetic Linkage
Humans
Male
Membrane Proteins
Middle Aged
Polymorphism, Genetic
Presenilin-1

Source

Open in PubMed

Identifiers

PMID: 10815136
DOI: 10.1001/archneur.57.5.699

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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