Presenilin 1 intronic polymorphism is not associated with Alzheimer type neuropathological changes or sporadic Alzheimer's disease.

doi:10.1136/jnnp.64.4.548

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Article

Presenilin 1 intronic polymorphism is not associated with Alzheimer type neuropathological changes or sporadic Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Apr 1998

Sodeyama N, Itoh Y, Suematsu N, Matsushita M, Otomo E, Mizusawa H, Yamada M

Abstract excerpt

BACKGROUND: A genetic association between the presenilin 1 (PS-1) intronic polymorphism and sporadic Alzheimer's disease has been a matter of controversy. Recent findings have suggested that the PS-1 polymorphism is not associated with Alzheimer's disease or amyloid beta-protein (Abeta) depositio...

Topics

Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease
Apolipoproteins E
Autopsy
Case-Control Studies
Disease Progression
Gene Frequency
Genotype
Humans
Introns
Membrane Proteins
Middle Aged
Polymorphism, Genetic

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Identifiers

PMID: 9576554
DOI: 10.1136/jnnp.64.4.548
PMCID: PMC2170047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9576554-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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