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Article

Presenilin 1 intronic polymorphism is not associated with Alzheimer type neuropathological changes or sporadic Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Apr 1998

Sodeyama N, Itoh Y, Suematsu N, Matsushita M, Otomo E, Mizusawa H, Yamada M

Abstract excerpt

BACKGROUND: A genetic association between the presenilin 1 (PS-1) intronic polymorphism and sporadic Alzheimer's disease has been a matter of controversy. Recent findings have suggested that the PS-1 polymorphism is not associated with Alzheimer's disease or amyloid beta-protein (Abeta) deposition in brains from patients with Alzheimer's disease. OBJECTIVES: To elucidate the influence of the PS-1 polymorphism on...

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Identifiers

PMID: 9576554
DOI: 10.1136/jnnp.64.4.548
PMCID: PMC2170047

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Presenilin 1 intronic polymorphism is not associated with Alzheimer type neuropathological changes or sporadic Alzheimer's disease.PMID 9576554Read ↗

Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease.Semantic proximity Read ↗

No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease.Semantic proximity Read ↗

No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease.Semantic proximity Read ↗

No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population.Semantic proximity Read ↗

Case-control study of presenilin-1 intronic polymorphism in sporadic early and late onset Alzheimer's disease.Semantic proximity Read ↗

No association between presenilin 1 (PS1) intronic polymorphism and sporadic Alzheimer's disease in Koreans.Semantic proximity Read ↗

No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples.Semantic proximity Read ↗

No association between the intronic presenilin 1 polymorphism and Alzheimer's disease in the Chinese population.Semantic proximity Read ↗

Presenilin-1 gene intronic polymorphism in sporadic and familial Alzheimer's disease.Semantic proximity Read ↗

No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia.Semantic proximity Read ↗

A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset.Semantic proximity Read ↗

Presenilin-1 gene intronic polymorphism and late-onset Alzheimer's disease.Semantic proximity Read ↗

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