Article
No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease.
Genetic epidemiology - 1 Jan 1997
Scott W K, Yamaoka L H, Locke P A, Rosi B L, Gaskell P C, Saunders A M, Conneally P M, Small G W, Farrer L A, Growdon J H, Roses A D, Pericak-Vance M A, Haines J L
Abstract excerpt
Recent reports have shown an association between an intronic polymorphism of the presenilin-1 (PSEN1) gene and late-onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent of the effect of the only previously identified...
Topics
- Age of Onset
- Aged
- Alzheimer Disease
- Female
- Gene Frequency
- Genotype
- Humans
- Introns
- Lod Score
- Male
- Membrane Proteins
- Middle Aged