A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset.

doi:10.1016/s0304-3940(97)00393-5

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Article

A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset.

Neuroscience letters - 13 Jun 1997

Lendon C L, Myers A, Cumming A, Goate A M, St Clair D

Abstract excerpt

Mutations in the presenilin 1 gene account for many cases of early onset familial Alzheimer's disease. Homozygosity for the 'T' allele of a polymorphism in the presenilin 1 gene has previously been reported to double the risk for Alzheimer's disease in a late onset Caucasian sample. Here we repor...

Topics

Adult
Age of Onset
Aged
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
DNA
Female
Genotype
Humans
Male
Membrane Proteins
Middle Aged
Polymorphism, Genetic
Presenilin-1
Risk
Scotland

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