Article
No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a Tunisian population.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Sept 2013
Rassas Afef Achouri, Fredj Sondess Hadj, Khiari Hela Mrabet, Sahnoun Safa, Bibi Amina, Siala Hajer, Mrabet Amel, Messaoud Taieb
Abstract excerpt
We examined the potential involvement of the polymorphism in intron 8 of the presenilin-1 (PSEN1) gene as a risk factor for Alzheimer disease (AD), both through independent effect and interaction with the apolipoprotein E (APOE) ε4 allele risk, in 85 patients and 90 controls. We found no significant differences in the distribution of PSEN1 genotype and allele frequency between both groups; and post stratification...
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