Article
Presenilin-1 intron 8 polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease.
Neuroscience letters - 24 Jan 1997
Tysoe C, Whittaker J, Cairns N J, Atkinson P F, Harrington C R, Xuereb J, Wilcock G, Rubinsztein D C
Abstract excerpt
Mutations in the presenilin-1 (PS-1) gene may account for the majority of familial early-onset Alzheimer's disease (EOAD) cases. However, there is controversy as to whether the bi-allelic intron 8 PS-1 polymorphism plays a role in late-onset AD (LOAD). As previous association studies with this polymorphism have all investigated clinically diagnosed LOAD cases, we have analysed the frequency of the PS-1 intronic...
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