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Article

Codeine in post-operative pain. Study of the influence of sparteine phenotype and serum concentrations of morphine and morphine-6-glucuronide.

European journal of clinical pharmacology - 1 Aug 1998

Poulsen L, Riishede L, Brøsen K, Clemensen S, Sindrup S H

Abstract excerpt

OBJECTIVE: Within the past decade, human experimental pain studies have supported the 50-year-old hypothesis that codeine is a prodrug, which has to be converted to morphine to exert an analgesic effect. This study aimed at evaluating the impact of sparteine phenotype and serum concentrations of...

Topics

Adult
Aged
Aged, 80 and over
Analgesics, Opioid
Codeine
Female
Humans
Male
Middle Aged
Morphine
Morphine Derivatives
Pain, Postoperative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Sparteine

Source

Identifiers

PMID: 9776433
DOI: 10.1007/s002280050491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9776433-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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