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Article

Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability.

British journal of anaesthesia - 1 Dec 2002

Williams D G, Patel A, Howard R F

Abstract excerpt

BACKGROUND: Codeine analgesia is wholly or mostly due to its metabolism to morphine by the cytochrome P450 enzyme CYP2D6, which shows significant genetic variation in activity. The aims of this study were to investigate genotype, phenotype and morphine production from codeine in children undergoing adenotonsillectomy, and to compare analgesia from codeine or morphine combined with diclofenac. METHODS: Ninety-six...

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Identifiers

PMID: 12453926
DOI: 10.1093/bja/aef284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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