CYP2D6 phenotype-specific codeine population pharmacokinetics.

doi:10.3109/15360288.2014.997854

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Article

CYP2D6 phenotype-specific codeine population pharmacokinetics.

Journal of pain & palliative care pharmacotherapy - 1 Mar 2015

Linares Oscar A, Fudin Jeffrey, Schiesser William E, Daly Linares Annemarie L, Boston Raymond C

Abstract excerpt

Codeine's metabolic fate in the body is complex, and detailed quantitative knowledge of it, and that of its metabolites is lacking among prescribers. We aimed to develop a codeine pharmacokinetic pathway model for codeine and its metabolites that incorporates the effects of genetic polymorphisms. We studied the phenotype-specific time courses of plasma codeine, codeine-6-glucoronide, morphine,...

Topics

Analgesics, Opioid
Codeine
Cytochrome P-450 CYP2D6
Humans
Male
Models, Biological
Morphine
Morphine Derivatives
Pharmacogenetics
Phenotype
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 25562725
DOI: 10.3109/15360288.2014.997854

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