Article
The pharmacogenetics of codeine hypoalgesia.
Pharmacogenetics - 1 Dec 1995
Sindrup S H, Brøsen K
Abstract excerpt
Codeine is an old drug that is still widely used to treat mild and moderate pain. It is mainly metabolised by glucuronidation, but minor pathways are N-demethylation to norcodeine and O-demethylation to morphine. The latter pathway depends on the genetically polymorphic CYP2D6 which is absent in...
Topics
- Analgesics, Opioid
- Codeine
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Drug Interactions
- Enzyme Inhibitors
- Humans
- Mixed Function Oxygenases
- Morphine
- Oxidation-Reduction
- Pain
- Pain Threshold
- Pharmacogenetics
- Phenotype
- Polymorphism, Genetic
- Sparteine