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Article

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype.

Clinical pharmacology and therapeutics - 1 Apr 1997

Mikus G, Trausch B, Rodewald C, Hofmann U, Richter K, Gramatté T, Eichelbaum M

Abstract excerpt

BACKGROUND: Codeine is widely used as an analgesic and antitussive drug. The analgesic effect of codeine is mediated by its metabolite morphine, which is formed by the polymorphically expressed enzyme CYP2D6; therefore poor metabolizers have no analgesia after administration of codeine. Like other opiates, codeine causes a delay of gastric emptying and spastic constipation. It is not yet known whether the effect...

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Identifiers

PMID: 9129563
DOI: 10.1016/S0009-9236(97)90196-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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