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Article

CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice.

The pharmacogenomics journal - 1 Aug 2021

Carranza-Leon Daniel, Dickson Alyson L, Gaedigk Andrea, Stein C Michael, Chung Cecilia P

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) O-demethylates codeine to the active drug, morphine. However, the utility of testing for CYP2D6 metabolizer status in patients receiving codeine in real-world clinical practice is poorly defined. Using data from a DNA bank linked to de-identified electronic health records, we studied 157 patients with a baseline pain score higher than 4 (0-10 scale) who received codeine. Based on...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33750887
DOI: 10.1038/s41397-021-00226-8
PMCID: PMC8295171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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