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Article

The postoperative pharmacokinetics of codeine.

European journal of clinical pharmacology - 1 Jan 1992

Persson K, Hammarlund-Udenaes M, Mortimer O, Rane A

Abstract excerpt

The metabolism and systemic availability of codeine have been studied in 12 patients after cholecystectomy. They were given 20 mg codeine as an IV bolus dose on the first day after surgery and 50 mg codeine as a single oral on the fourth day after surgery. Codeine had a medium to high extraction ratio and a total plasma clearance of 10.8 (4.3) ml.min-1.kg-1. The clearance varied four-fold between subjects. All...

Topics

Adult
Aged
Codeine
Dextromethorphan
Female
Humans
Male
Middle Aged
Phenotype
Postoperative Period

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1623909
DOI: 10.1007/BF00265933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1623909-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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