Article
Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan.
British journal of clinical pharmacology - 1 Feb 1995
Persson K, Sjöström S, Sigurdardottir I, Molnár V, Hammarlund-Udenaes M, Rane A
Abstract excerpt
Postoperative pain relief with codeine was evaluated in 11 women undergoing hysterectomy. Patient-controlled analgesia (PCA) was used to administer codeine. After the study the patients were phenotyped with respect to the O-demethylation of dextromethorphan (cytochrome P4502D6 polymorphism). Ten...
Topics
- Adult
- Aged
- Analgesia, Patient-Controlled
- Codeine
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Dextromethorphan
- Female
- Genotype
- Humans
- Middle Aged
- Mixed Function Oxygenases
- Pain, Postoperative
- Phenotype