Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism.

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Article

Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism.

The Journal of pharmacology and experimental therapeutics - 1 Feb 1994

Mikus G, Bochner F, Eichelbaum M, Horak P, Somogyi A A, Spector S

Abstract excerpt

Codeine and morphine are endogenous substances. Following administration of exogenous codeine the biotransformation to morphine is catalyzed by CYP2D6, which exhibits a genetic so-called debrisoquine/sparteine polymorphism which is expressed in two phenotypes, the extensive and poor metaboliser p...

Topics

Adult
Codeine
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Female
Humans
Male
Middle Aged
Mixed Function Oxygenases
Morphine
Phenotype
Polymorphism, Genetic
Quinidine

Source

Open in PubMed

Identifiers

PMID: 8113966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8113966-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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