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Article

Codeine: Time to Say "No".

Pediatrics - 1 Oct 2016

Tobias Joseph D, Green Thomas P, Coté Charles J

Abstract excerpt

Codeine has been prescribed to pediatric patients for many decades as both an analgesic and an antitussive agent. Codeine is a prodrug with little inherent pharmacologic activity and must be metabolized in the liver into morphine, which is responsible for codeine's analgesic effects. However, there is substantial genetic variability in the activity of the responsible hepatic enzyme, CYP2D6, and, as a consequence,...

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Identifiers

PMID: 27647717
DOI: 10.1542/peds.2016-2396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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