Article
Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation.
Pain - 1 May 1998
Eckhardt K, Li S, Ammon S, Schänzle G, Mikus G, Eichelbaum M
Abstract excerpt
The analgesic effect and adverse events of the weak opioid codeine is assumed to be mediated by its metabolite morphine. The cytochrome P-450 enzyme CYP2D6 catalysing the formation of morphine exhibits a genetic polymorphism. Two distinct phenotypes, the extensive (EMs) and poor metabolisers (PMs), are present in the population. The prevalence of PMs in the Caucasian population is 7% to 10%. Since PMs do not...
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