Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation.

doi:10.1016/s0304-3959(98)00021-9

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Article

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation.

Pain - 1 May 1998

Eckhardt K, Li S, Ammon S, Schänzle G, Mikus G, Eichelbaum M

Abstract excerpt

The analgesic effect and adverse events of the weak opioid codeine is assumed to be mediated by its metabolite morphine. The cytochrome P-450 enzyme CYP2D6 catalysing the formation of morphine exhibits a genetic polymorphism. Two distinct phenotypes, the extensive (EMs) and poor metabolisers (PMs...

Topics

Adult
Analgesics, Opioid
Area Under Curve
Codeine
Cytochrome P-450 CYP2D6
Double-Blind Method
Female
Genotype
Humans
Male
Morphine
Pain Measurement
Phenotype

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