Article
Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?
Pain - 1 Jun 1993
Sindrup Søren H, Poulsen Lars, Brøsen Kim, Arendt-Nielsen Lars, Gram Lars F
Abstract excerpt
It has recently been shown that O-demethylation of the opioid drug codeine to morphine depends on the sparteine/debrisoquine oxygenase (CYP2D6) which in man exhibits genetic polymorphism. Morphine may be an endogenously formed substance in mammalians. Therefore, it may be hypothesized that the fi...
Topics
- Adult
- Brain
- Codeine
- Cold Temperature
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Female
- Humans
- Liver
- Male
- Middle Aged
- Mixed Function Oxygenases
- Pain
- Pain Measurement
- Phenotype
- Sparteine