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Article

Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

Pain - 1 Jun 1993

Sindrup Søren H, Poulsen Lars, Brøsen Kim, Arendt-Nielsen Lars, Gram Lars F

Abstract excerpt

It has recently been shown that O-demethylation of the opioid drug codeine to morphine depends on the sparteine/debrisoquine oxygenase (CYP2D6) which in man exhibits genetic polymorphism. Morphine may be an endogenously formed substance in mammalians. Therefore, it may be hypothesized that the final step in an endogenous synthesis of morphine from codeine also depends on CYP2D6. CYP2D6, which is present in the...

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Identifiers

PMID: 8351162
DOI: 10.1016/0304-3959(93)90229-I

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?PMID 8351162Read ↗

Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism.Semantic proximity Read ↗

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Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans.Semantic proximity Read ↗

The Hypoalgesic Effect of Oxycodone in Human Experimental Pain Models in Relation to the CYP2D6 Oxidation PolymorphismSemantic proximity Read ↗

The pharmacogenetics of codeine hypoalgesia.Semantic proximity Read ↗

Codeine in post-operative pain. Study of the influence of sparteine phenotype and serum concentrations of morphine and morphine-6-glucuronide.Semantic proximity Read ↗

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