NMR study on the impact of metal ion binding and deoxynucleotide substitution upon local structure and stability of a small ribozyme.

doi:10.1016/s0014-5793(98)00906-5

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Article

NMR study on the impact of metal ion binding and deoxynucleotide substitution upon local structure and stability of a small ribozyme.

FEBS letters - 21 Aug 1998

Vogtherr M, Limmer S

Abstract excerpt

We have studied a very small ribozyme described earlier which requires the presence of soft metal ions like manganese or cadmium. It consists of only three uridines as ribozyme, cleaving the sequence 5'-GAAA-3' after the guanosine. We have set out to characterize the metal ion binding in this sys...

Topics

Adenosine
Base Composition
Base Sequence
Binding Sites
Cadmium
Cations, Divalent
Genetic Variation
Guanosine
Nuclear Magnetic Resonance, Biomolecular
Nucleic Acid Conformation
Oligoribonucleotides
Point Mutation
RNA, Catalytic

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