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Article

NMR study on the impact of metal ion binding and deoxynucleotide substitution upon local structure and stability of a small ribozyme.

FEBS letters - 21 Aug 1998

Vogtherr M, Limmer S

Abstract excerpt

We have studied a very small ribozyme described earlier which requires the presence of soft metal ions like manganese or cadmium. It consists of only three uridines as ribozyme, cleaving the sequence 5'-GAAA-3' after the guanosine. We have set out to characterize the metal ion binding in this system by NMR spectroscopy and the impact of the ribose 2'-OH group of the cleavable nucleotide upon local structure. NMR...

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Identifiers

PMID: 9744815
DOI: 10.1016/s0014-5793(98)00906-5

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