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Article

Effect of metal ion binding on the structural stability of the hepatitis C virus RNA polymerase.

The Journal of biological chemistry - 26 Nov 2004

Benzaghou Ines, Bougie Isabelle, Bisaillon Martin

Abstract excerpt

The RNA polymerase activity of the hepatitis C virus, a major human pathogen, has previously been shown to be supported by metal ions. In the present study, we report a systematic analysis of the effect of metal ion binding on the structural stability of the hepatitis C virus RNA polymerase. Chemical and thermal denaturation assays revealed that the stability of the protein is increased significantly in the...

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PMID: 15375162
DOI: 10.1074/jbc.M409657200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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