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Article

A conformational switch controls hepatitis delta virus ribozyme catalysis.

Nature - 13 May 2004

Ke Ailong, Zhou Kaihong, Ding Fang, Cate Jamie H D, Doudna Jennifer A

Abstract excerpt

Ribozymes enhance chemical reaction rates using many of the same catalytic strategies as protein enzymes. In the hepatitis delta virus (HDV) ribozyme, site-specific self-cleavage of the viral RNA phosphodiester backbone requires both divalent cations and a cytidine nucleotide. General acid-base catalysis, substrate destabilization and global and local conformational changes have all been proposed to contribute to...

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Identifiers

PMID: 15141216
DOI: 10.1038/nature02522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A conformational switch controls hepatitis delta virus ribozyme catalysis.PMID 15141216Read ↗

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General acid catalysis by the hepatitis delta virus ribozyme.Semantic proximity Read ↗

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