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Article

NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2010

Koutmou Kristin S, Casiano-Negroni Anette, Getz Melissa M, Pazicni Samuel, Andrews Andrew J, Penner-Hahn James E, Al-Hashimi Hashim M, Fierke Carol A

Abstract excerpt

Functionally critical metals interact with RNA through complex coordination schemes that are currently difficult to visualize at the atomic level under solution conditions. Here, we report a new approach that combines NMR and XAS to resolve and characterize metal binding in the most highly conser...

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Identifiers

PMID: 20133747
DOI: 10.1073/pnas.0906319107
PMCID: PMC2823894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20133747-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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