Article
Presence of a coordinated metal ion in a trans-acting antigenomic delta ribozyme.
Nucleic acids research - 1 Aug 1999
Lafontaine D A, Ananvoranich S, Perreault J P
Abstract excerpt
We have investigated the cleavage induced by metal ions in an antigenomic form of a trans-acting delta ribozyme. A specific Mg(2+)-induced cleavage at position G(52)at the bottom of the P2 stem was observed to occur solely within catalytically active ribozyme-substrate complexes (i.e. those that performed the essential conformational transition step). Only the divalent cations which support catalytic activity...
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