Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metal ion cooperativity in ribozyme cleavage of RNA.

Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2001

Brännvall M, Kirsebom L A

Abstract excerpt

Combinations of chemical and genetic approaches were used to study the function of divalent metal ions in cleavage of RNA by the ribozyme RNase P RNA. We show that different divalent metal ions have differential effects on cleavage site recognition and rescue of cleavage activity by mixing divalent metal ions that do not promote cleavage by themselves. We conclude that efficient and correct cleavage is the result...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA, Catalytic
Share to Base Sequence
Share to Endoribonucleases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Metals

Share to Nucleic Acid Conformation

Share to Ribonuclease P

Source

Open in PubMed Open full text

Identifiers

PMID: 11606743
DOI: 10.1073/pnas.221456598
PMCID: PMC60804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metal ion cooperativity in ribozyme cleavage of RNA.PMID 11606743Read ↗

In vitro selection for altered divalent metal specificity in the RNase P RNA.Semantic proximity Read ↗

Conservation of helical structure contributes to functional metal ion interactions in the catalytic domain of ribonuclease P RNA.Semantic proximity Read ↗

Coordination of divalent metal ions in the active site of poly(A)-specific ribonuclease.Semantic proximity Read ↗

Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis.Semantic proximity Read ↗

Presence of a coordinated metal ion in a trans-acting antigenomic delta ribozyme.Semantic proximity Read ↗

A conformational switch controls hepatitis delta virus ribozyme catalysis.Semantic proximity Read ↗

Magnesium dependence of the amplified conformational switch in the trans-acting hepatitis delta virus ribozyme.Semantic proximity Read ↗

The pre-tRNA nucleotide base and 2'-hydroxyl at N(-1) contribute to fidelity in tRNA processing by RNase P.Semantic proximity Read ↗

Evolution in vitro of an RNA enzyme with altered metal dependence.Semantic proximity Read ↗

Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations.Semantic proximity Read ↗

Mg2+-independent hairpin ribozyme catalysis in hydrated RNA films.Semantic proximity Read ↗

Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.