Article
Magnesium dependence of the amplified conformational switch in the trans-acting hepatitis delta virus ribozyme.
Biochemistry - 20 Jul 2004
Tinsley Rebecca A, Harris Dinari A, Walter Nils G
Abstract excerpt
The ability of divalent metal ions to participate in both structure formation and catalytic chemistry of RNA enzymes (ribozymes) has made it difficult to separate their cause and effect in ribozyme function. For example, the recently solved crystal structures of precursor and product forms of the cis-cleaving genomic hepatitis delta virus (HDV) ribozyme show a divalent metal ion bound in the active site that is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.