Reduced levels of substance P in the brains of Cpe(fat)/Cpe(fat) mice.

doi:10.1016/s0196-9781(98)00010-2

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Article

Reduced levels of substance P in the brains of Cpe(fat)/Cpe(fat) mice.

Peptides - 1 Jan 1998

Perloff M D, Kream R M, Beinfeld M C

Abstract excerpt

This study examines the role of carboxypeptidase E (CPE) in processing pro tachykinin to form the final bioactive amidated undecapeptide, substance P (SP) in various rat brain regions. Cpe(fat)/Cpe(fat) mice brain tissue was analyzed for total SP forms (including intermediates), and final amidate...

Topics

Animals
Brain
Carboxypeptidase H
Carboxypeptidases
Mice
Mutation
Radioimmunoassay
Rats
Substance P

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