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Article

Reduced levels of substance P in the brains of Cpe(fat)/Cpe(fat) mice.

Peptides - 1 Jan 1998

Perloff M D, Kream R M, Beinfeld M C

Abstract excerpt

This study examines the role of carboxypeptidase E (CPE) in processing pro tachykinin to form the final bioactive amidated undecapeptide, substance P (SP) in various rat brain regions. Cpe(fat)/Cpe(fat) mice brain tissue was analyzed for total SP forms (including intermediates), and final amidated SP was compared to Cpe+/Cpe+ and Cpe+/Cpe- controls. In all brain regions tested by radioimmunoassay, amidated fully...

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Source

Identifiers

PMID: 9700764
DOI: 10.1016/s0196-9781(98)00010-2

Genes

CPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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