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Article

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.

Nature genetics - 1 Jun 1995

Naggert J K, Fricker L D, Varlamov O, Nishina P M, Rouille Y, Steiner D F, Carroll R J, Paigen B J, Leiter E H

Abstract excerpt

Mice homozygous for the fat mutation develop obesity and hyperglycaemia that can be suppressed by treatment with exogenous insulin. The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin. We now demonstrate a defect in proinsulin processing associated with the virtual absence of CPE...

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Identifiers

PMID: 7663508
DOI: 10.1038/ng0695-135

Genes

CPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.PMID 7663508Read ↗

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene.Semantic proximity Read ↗

Genetic modifiers interact with Cpe(fat) to affect body weight, adiposity, and hyperglycemia.Semantic proximity Read ↗

Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus.Semantic proximity Read ↗

Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism.Semantic proximity Read ↗

Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.Semantic proximity Read ↗

Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice.Semantic proximity Read ↗

The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.Semantic proximity Read ↗

Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.Semantic proximity Read ↗

A New Cause of Obesity Syndrome Associated with a Mutation in the Carboxypeptidase Gene Detected in Three Siblings with Obesity, Intellectual Disability and Hypogonadotropic HypogonadismSemantic proximity Read ↗

Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice.Semantic proximity Read ↗

Carboxypeptidase E and obesity in the mouse.Semantic proximity Read ↗

Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.Semantic proximity Read ↗

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