Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.

doi:10.1038/ng0695-135

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Article

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.

Nature genetics - 1 Jun 1995

Naggert J K, Fricker L D, Varlamov O, Nishina P M, Rouille Y, Steiner D F, Carroll R J, Paigen B J, Leiter E H

Abstract excerpt

Mice homozygous for the fat mutation develop obesity and hyperglycaemia that can be suppressed by treatment with exogenous insulin. The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin. We now demonstrate a defect in proinsulin processing associated with the virtual absence of CPE...

Topics

Amino Acid Sequence
Animals
Base Sequence
Carboxypeptidase B
Carboxypeptidase H
Carboxypeptidases
Cattle
Chromosome Mapping
Conserved Sequence
Enzyme Activation
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Islets of Langerhans

Male

Mice

Mice, Inbred C57BL

Mice, Inbred NOD

Mice, Obese

Mice, SCID

Source

Open in PubMed

Identifiers

PMID: 7663508
DOI: 10.1038/ng0695-135

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7663508-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.PMID 7663508Read ↗

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