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Article

Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jun 2016

Höfling Corinna, Kulesskaya Natalia, Jaako Külli, Peltonen Iida, Männistö Pekka T, Nurmi Antti, Vartiainen Nina, Morawski Markus, Zharkovsky Alexander, Võikar Vootele, Roßner Steffen, García-Horsman J Arturo

Abstract excerpt

Prolyl oligopeptidase (PREP) has been implicated in neurodegeneration and neuroinflammation and has been considered a drug target to enhance memory in dementia. However, the true physiological role of PREP is not yet understood. In this paper, we report the phenotyping of a mouse line where the PREP gene has been knocked out. This work indicates that the lack of PREP in mice causes reduced anxiety but also...

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Identifiers

PMID: 26996375
DOI: 10.1016/j.euroneuro.2016.02.015

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PREP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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