Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.

The Journal of biological chemistry - 13 Dec 2002

Nillni Eduardo A, Xie Weihua, Mulcahy Lawrence, Sanchez Vanesa C, Wetsel William C

Abstract excerpt

Cpe(fat/fat) mice are obese, diabetic, and infertile. They have a mutation in carboxypeptidase E (CPE), an enzyme that converts prohormone intermediates to bioactive peptides. The Cpe(fat) mutation leads to rapid degradation of the enzyme. To test whether pro-thyrotropin-releasing hormone (TRH) conversion to TRH involves CPE, processing was examined in the Cpe(fat/fat) mouse. Hypothalamic TRH is depressed by at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Temperature Regulation
Share to Homozygote

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypothalamo-Hypophyseal System

Share to Mice, Mutant Strains

Share to Protein Precursors

Share to Protein Processing, Post-Translational

Share to Sequence Homology, Amino Acid

Share to Thyroid Gland

Source

Identifiers

PMID: 12270926
DOI: 10.1074/jbc.M206702200

Genes

TRH
CPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.PMID 12270926Read ↗

Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice.Semantic proximity Read ↗

The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.Semantic proximity Read ↗

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.Semantic proximity Read ↗

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene.Semantic proximity Read ↗

Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism.Semantic proximity Read ↗

Reduced levels of substance P in the brains of Cpe(fat)/Cpe(fat) mice.Semantic proximity Read ↗

Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus.Semantic proximity Read ↗

Hypothalamic proopiomelanocortin processing and the regulation of energy balance.Semantic proximity Read ↗

Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice.Semantic proximity Read ↗

A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice.Semantic proximity Read ↗

Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior.Semantic proximity Read ↗

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.