Article
Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice.
Endocrinology - 1 Apr 2004
Srinivasan Sudha, Bunch Donna O, Feng Yun, Rodriguiz Ramona M, Li Min, Ravenell Roneka L, Luo Guo X, Arimura Akira, Fricker Lloyd D, Eddy Edward M, Wetsel William C
Abstract excerpt
Cpe(fat/fat) mice are obese, diabetic, and infertile. These animals have a point mutation in carboxypeptidase E (CPE), an exopeptidase that removes C-terminal basic amino acids from peptide intermediates. The mutation renders the enzyme unstable, and it is rapidly degraded. Although the infertility of Cpe(fat/fat) mice has not been systematically investigated, it is thought to be due to a deficit in GnRH...
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