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Article

Carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina.

Journal of neurochemistry - 1 Dec 2005

Zhu Xuemei, Wu Kebin, Rife Lawrence, Cawley Niamh X, Brown Bruce, Adams Tiffany, Teofilo Karen, Lillo Concepcion, Williams David S, Loh Y Peng, Craft Cheryl M

Abstract excerpt

Defects in the gene encoding carboxypeptidase E (CPE) in either mouse or human lead to multiple endocrine disorders, including obesity and diabetes. Recent studies on Cpe-/- mice indicated neurological deficits in these animals. As a model system to study the potential role of CPE in neurophysiology, we carried out electroretinography (ERG) and retinal morphological studies on Cpe-/- and Cpe fat/fat mutant mice....

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Source

Identifiers

PMID: 16219026
DOI: 10.1111/j.1471-4159.2005.03460.x

Genes

CPE
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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